Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycleSARS-CoV-2 스파이크 단백질 요소와의 Decavanadate 상호 작용은 감염 주기를 방해하는 정전기의 잠재적 역할을 강조합니다Article Published on 2022-09-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent approach association binding biological properties biological property carried collected data coronavirus COVID-19 cytotoxicity decrease disrupt disrupting drug design effective Effectiveness effort electrostatic force electrostatic forces element ENhance Evidence furin furin cleavage site highlight Host host cell host cell membrane identify In vitro studies in vitro study infected cells Interaction interactions less mass spectrometry molecular Native Novel coronavirus Polyanion polybasic Polyoxidometalate Protein Protein binding Proteolytic processing provide receptor Receptor-binding domain robust robustness Safe SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 spike protein shown Spike protein the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic therapeutic agent therapeutic agents Therapeutics utility Vanadium Vanadium. variety Viral mutations while [DOI] 10.1016/j.jinorgbio.2022.111899 PMC 바로가기 [Article Type] Article
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into CellsArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral entry. viral surface virus virus entry virus infection viruses were infected wild-type [DOI] 10.1128/spectrum.00870-22 PMC 바로가기
Culture and identification of a “Deltamicron” SARS-CoV-2 in a three cases cluster in southern France프랑스 남부의 3개 사례 클러스터에서 "델타마이크론" SARS-CoV-2의 배양 및 식별Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] backbone binding Chain Reaction clinical feature Cluster Co-infection codon Codons composed Coronaviruses Delta deltamicron Diagnosis electron microscopy Epidemic epidemiological France full-length Genetic Genome host cell host cell membrane Infection isolate Lineage lineages Microscopy Multiple Mutation nucleotide omicron polymerase chain polymerase chain reaction qPCR Quantitative quantitative polymerase chain reaction recombinant reported SARS-CoV-2 SARS-CoV-2 variant scanning electron microscopy sequenced sequencing depth spike gene Spread Structural analysis suggested summer supported variant Variant. Virological [DOI] 10.1002/jmv.27789 PMC 바로가기 [Article Type] Article
An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infectionResearch article Published on 2022-08-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2 [DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses이중막 소포(DMV): SARS-CoV-2 및 기타 포지티브 센스 단일 가닥 RNA 바이러스 복제 전용 바이러스 유도 소기관Review Published on 2022-07-162022-09-11 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogy Antiviral approach autophagic biogenesis can not Cell organelle coronavirus COVID-19 Double-membrane vesicle Endoplasmic reticulum export Genome Golgi apparatus HCV hepatitis C hepatitis C virus host cell host cell membrane host cell membranes induce initial Innate immunity interactions involved lipid droplet lipid droplets lipids mechanism mechanisms membrane metabolite metabolites Mitochondria morphology non-structural protein organelle other coronavirus other coronaviruses pathogen phylogenetically positive-sense single-stranded RNA Positive-sense single-stranded RNA virus Replication replication of SARS-CoV-2 Replication organelle required RNA RNA virus SARS-CoV-2 sealed shown similarity single-stranded storage supply these viruses Vesicle viral replication Viral RNA virions virus Virus/cell interactions. viruses [DOI] 10.1007/s00018-022-04469-x PMC 바로가기 [Article Type] Review
Peptide mediated colorimetric detection of SARS-CoV-2 using gold nanoparticles: a molecular dynamics simulation study금 나노입자를 이용한 SARS-CoV-2의 펩티드 매개 비색 검출: 분자 역학 시뮬레이션 연구Article Published on 2022-06-242022-09-11 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding Clinical diagnosis colorimetric detection coronavirus COVID-19 detection domain enzyme gold Gold nanoparticle host cell host cell membrane in silico interact Interaction investigated methodology molecular molecular dynamics Molecular dynamics simulation outbreak peptide peptides RBD receptor Receptor-binding domain resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2. screened selective severe acute respiratory syndrome Coronavirus spike Spike protein spike protein of SARS-CoV-2 spikes stability the spike protein virus [DOI] 10.1007/s00894-022-05184-x PMC 바로가기 [Article Type] Article
Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19펩티드 기반 치료제: COVID-19에 대한 새로운 잠재적 치료제Review Published on 2022-05-012022-09-11 Journal: Thérapie [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] antimicrobial peptide antiviral activity Antiviral agents blocked causative agent cell membrane cleave clinical trials COVID-19 COVID-19 outbreak drug drugs feasibility form fusion hACE2 host cell host cell membrane Human humans In silico method inhibitor Interaction intestine intestines lactoferrin lung Lungs mechanism MERS outbreak pandemic peptide peptide-based peptides Peptides-based therapeutics positive-sense RNA virus potential therapeutic agent RNA virus S protein S protein-hACE2 interaction S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2. shown the S1 subunit the SARS-CoV-2 therapeutic viral envelope viral infection [DOI] 10.1016/j.therap.2021.09.007 PMC 바로가기 [Article Type] Review
A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and AntibodyReview Published on 2022-02-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] α5-N-acetylneuraminic acid (Neu5Ac) ACE2 betacoronavirus Betacoronavirus bind binding Blood CD147 clinical testing common cold COVID-19 COVID-19 patient enzyme Express expressed glycan glycophorin A hemagglutination hemagglutinin esterase host cell membrane host cells in silico in vitro Mediated MERS N-glycosylation site RBC RBCs Red red blood cell Release Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein sialic acid spike Spike protein strain Strains surface therapeutic virulent virus virus strain [DOI] 10.3390/ijms23052558 PMC 바로가기 [Article Type] Review
RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 ReceptorArticle Published on 2021-12-212022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor addition antibody antibody escape binding binding energy catastrophic caused coding region constant COVID-19 pandemic demonstrated enhanced Evolution of SARS-CoV-2 free energy generate Genome Health host cell membrane host cells increase initial Interaction investigated MD simulations MM/GBSA molecular Molecular dynamics simulation mutant mutated Mutation outbreak RBD SARS-CoV-2 SARS-COV-2 infection single mutation Spike protein strain the RBD the receptor-binding domain the spike protein Transmissibility transmissibility of SARS-CoV-2 variants virus genome [DOI] 10.3390/v14010001 PMC 바로가기 [Article Type] Article
Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer SimulationsImmunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Affect affinity antibody approach assessment bind binding affinities binding affinity Biomolecule can be used cause change circulating computer Coronavirus disease 2019 COVID-19 domain Dynamics Effect experimental work expression facilitate hACE2 hACE2 receptor helping host cell membrane hotspot Human human ACE2 human Angiotensin-converting enzyme infect Infection modulate molecular dynamics mutated Mutation mutations Neutralizing Neutralizing antibodies protein-protein interaction protocol Rapid S-RBD S1 domain S2 domain SARS-CoV-2 SARS-CoV-2 genome Screening selected Simulation spike spike glycoprotein Spike protein Spike-RBD the binding affinity time-consuming vaccination variant virus [DOI] 10.3389/fimmu.2021.730099 PMC 바로가기 [Article Type] Immunology